How changes in sugar molecules affect inflammation and immune response in people with HIV
Official title: Glycomic Modulation of Inflammaging and Immune Functions during HIV Infection
Funded at Northwestern University at Chicago · NIH-11084597 · Data updated 2026-11-12
This study is looking at how changes in sugar molecules on antibodies might help us understand and predict inflammation-related health issues in people with HIV who are on treatment, with the goal of finding new ways to prevent and treat these problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | January 15, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $527,129 |
| NIH project number | 1R01AG092241-01 |
| Project ID | NIH-11084597 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who are currently receiving antiretroviral therapy.
✕Less likely to help
Patients who are not living with HIV or those not on antiretroviral therapy may not benefit from this research.
What this research studies
This research investigates how alterations in sugar molecules attached to antibodies may predict and influence inflammation-related health issues in individuals living with HIV who are on antiretroviral therapy. The study aims to identify specific biomarkers that indicate the risk of developing these comorbidities and to explore new strategies for prevention and treatment. By analyzing the glycomic changes in circulating IgGs, the research seeks to understand their role in exacerbating inflammation and immune dysfunction associated with aging and HIV. Patients may be monitored over time to assess the relationship between these glycomic changes and health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for predicting and managing inflammation-related health issues in people living with HIV.
How similar studies have gone: Previous research has shown promising results in identifying biomarkers related to inflammation and aging, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Abdel Mohsen, Mohamed — Northwestern University at Chicago
- Study coordinator: Abdel Mohsen, Mohamed
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.