How changes in red blood cell function affect heart health in kidney disease patients
Official title: Dynamic Changes in Erythrocyte 2,3 DPG as a Driver of Cardiac Dysfunction in End Stage Kidney Disease
Funded at VA Greater Los Angeles Healthcare System · NIH-10909836 · Data updated 2026-11-12
This study is looking at how changes in certain substances in your red blood cells might affect heart health for people with severe kidney disease who are on dialysis, with the goal of finding better ways to help keep your heart healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| NIH project number | 5IK2CX002195-04 |
| Project ID | NIH-10909836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans and other patients undergoing hemodialysis for end-stage renal disease.
✕Less likely to help
Patients who are not on dialysis or those with early-stage kidney disease may not benefit from this research.
What this research studies
This research investigates how alterations in red blood cell metabolites, specifically 2,3-DPG, contribute to heart problems in patients with end-stage renal disease (ESRD) undergoing dialysis. By examining the relationship between these changes and cardiovascular events, the study aims to identify new therapeutic strategies to improve heart health in this vulnerable population. The research will utilize both laboratory models and patient data to explore these connections and their implications for treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved cardiovascular outcomes and reduced mortality for patients with end-stage kidney disease.
How similar studies have gone: Previous research has shown promising results in understanding the cardiovascular risks associated with dialysis, suggesting that this approach may yield valuable insights.
Where this research is happening
-
VA Greater Los Angeles Healthcare System
Los Angeles, United States Active
Researchers
- Principal investigator: Sharma, Shilpa — VA Greater Los Angeles Healthcare System
- Study coordinator: Sharma, Shilpa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.