How changes in opioid prescriptions affect cannabis use and pain management outcomes

Impact of Prescription Opioid Dose Changes on Cannabis Use and Clinical Outcomes

NIH-funded research Oregon Health & Science University · NIH-10617329

This study is looking at how changing opioid doses affects cannabis use in people with chronic pain, and it’s for patients who are currently using both opioids and cannabis to manage their pain.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionOregon Health & Science University NIH-funded
Lab location1 site (Portland, United States)
Project IDNIH-10617329 on NIH RePORTER

What this research studies

This research investigates the relationship between changes in prescription opioid doses and cannabis use among patients with chronic pain. It aims to understand how discontinuing opioids may influence patients' use of cannabis for pain relief and the associated clinical outcomes. The study will involve 650 participants who are currently prescribed long-term opioid therapy and have tested positive for cannabis. Participants will provide self-reported data on their cannabis use and opioid doses over a two-year period, allowing researchers to gather comprehensive insights into these dynamics.

Who could benefit from this research

Good fit: Ideal candidates for this research are patients who are currently on long-term opioid therapy and use cannabis for pain management.

Not a fit: Patients who do not use cannabis or are not prescribed opioids may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide valuable insights into alternative pain management strategies that reduce reliance on opioids.

How similar studies have performed: Previous studies have suggested a correlation between cannabis use and reduced opioid prescriptions, indicating potential for success in this area of research.

Where this research is happening

Portland, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.