How changes in mitochondrial function affect blood vessel health
Critical role of Mitochondrial Fission/Fusion in Regulation of Microvascular Endothelial Function
This study looks at how tiny changes in the cells of your blood vessels affect blood flow, especially for people with coronary artery disease, and aims to find new ways to improve heart health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10880608 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial fission and fusion in regulating blood flow in small blood vessels, particularly in patients with coronary artery disease (CAD). It focuses on how aging and other cardiovascular risk factors can lead to impaired microvascular function, which is crucial for heart health. By examining the mechanisms that switch the signaling from nitric oxide to hydrogen peroxide in blood vessels, the study aims to uncover new ways to improve blood flow and reduce tissue damage. Patients with CAD may benefit from understanding these processes, which could lead to better treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with coronary artery disease, particularly those who are older or have other cardiovascular risk factors.
Not a fit: Patients without coronary artery disease or those who do not have risk factors for cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for coronary artery disease by enhancing microvascular function.
How similar studies have performed: Other research has shown promising results in understanding the role of mitochondrial function in cardiovascular health, suggesting that this approach could lead to significant advancements.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Beyer, Andreas M — Medical College of Wisconsin
- Study coordinator: Beyer, Andreas M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.