How changes in metabolism and the epigenome affect sleep patterns in Alzheimer's disease
Official title: The epigenome-metabolism nexus as a driver of circadian disruption in Alzheimer's disease
Funded at Purdue University · NIH-11163912 · Data updated 2026-11-12
This study is looking at how changes in sleep patterns and metabolism might be linked to Alzheimer's disease, using fruit flies to help understand the connections and find new ways to help treat the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | May 15, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $419,005 |
| NIH project number | 1R21AG094190-01 |
| Project ID | NIH-11163912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing symptoms of Alzheimer's disease or related dementias.
✕Less likely to help
Patients who are under 21 years old or do not have any form of Alzheimer's disease or related dementia may not benefit from this research.
What this research studies
This research investigates the relationship between circadian rhythms, metabolism, and Alzheimer's disease. It explores how disruptions in sleep patterns may not only be symptoms of Alzheimer's but could also play a role in its development. Using fruit fly models, the study aims to identify the underlying mechanisms that connect metabolic changes to circadian disruptions. By examining the molecular processes involved, the research seeks to uncover potential targets for therapeutic intervention.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing sleep disturbances in Alzheimer's patients, potentially slowing disease progression.
How similar studies have gone: Previous research has shown promising results in understanding the connection between circadian rhythms and neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Weake, Vikki Marie — Purdue University
- Study coordinator: Weake, Vikki Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.