How changes in metabolism affect lung stem cells in pulmonary fibrosis
Metabolic Reprogramming of the Alveolar Stem Cell Niche in Pulmonary Fibrosis
This study is looking at how changes in metabolism affect lung stem cells, especially in people with pulmonary fibrosis, to see if a specific enzyme can help us understand how lung cells behave during injury and healing, which could lead to new treatments for lung diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11057707 on NIH RePORTER |
What this research studies
This research investigates how metabolic changes influence the behavior of alveolar stem cells in the lungs, particularly in the context of pulmonary fibrosis. It focuses on the interactions between different cell types in the lung and how these interactions can be altered by metabolic enzymes. By studying the role of a specific enzyme, nicotinamide N-methyltransferase (NNMT), the research aims to understand how it affects the transition of certain lung cells during injury and repair processes. The findings could provide insights into new therapeutic strategies for lung diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with pulmonary fibrosis.
Not a fit: Patients with other lung conditions that do not involve pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function and quality of life for patients with pulmonary fibrosis.
How similar studies have performed: Other research has shown promising results in understanding metabolic pathways in lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Thannickal, Victor J. — Tulane University of Louisiana
- Study coordinator: Thannickal, Victor J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.