How changes in gene regulation affect aging and longevity
Molecular mechanisms linking epigenetic changes to longevity
This study is looking at how changes in our genes as we age might affect our health and lifespan, and it aims to find ways to help people live healthier, longer lives by understanding these changes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10983735 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that connect epigenetic changes to the aging process. By studying the effects of specific chromatin alterations in model organisms, the researchers aim to understand how these changes influence gene expression and metabolic processes that may extend lifespan. The study focuses on the role of certain proteins and transcription factors in regulating these epigenetic modifications and their impact on age-related diseases. Patients may benefit from insights gained into how to potentially mitigate the effects of aging through targeted interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related health issues or those interested in longevity and healthy aging.
Not a fit: Patients with acute, non-age-related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting longevity and reducing the incidence of age-related diseases.
How similar studies have performed: Other research has shown promising results in understanding the role of epigenetics in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Silva-Garcia, Carlos Giovanni — Brown University
- Study coordinator: Silva-Garcia, Carlos Giovanni
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.