How changes in chromatin structure affect cancer development and progression
The impact of changes in chromatin architecture on cancer phenotypes and tumor progression
This study is looking at how the way DNA is organized in our cells can affect gene activity and cancer growth, especially in types like Acute B-Lymphocytic Leukemia, to find new ways to understand and treat the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11015495 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin architecture in cancer, particularly focusing on how the organization of DNA within cells influences gene expression and tumor behavior. By examining the three-dimensional structure of chromatin, researchers aim to understand how specific changes can lead to the development of cancers like Acute B-Lymphocytic Leukemia. The study employs advanced techniques to analyze chromatin interactions and regulatory elements, which may reveal new insights into cancer biology and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with Acute B-Lymphocytic Leukemia or related B-cell malignancies.
Not a fit: Patients with solid tumors or other non-hematological cancers may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating cancers by targeting chromatin structure and function.
How similar studies have performed: Previous research has shown promising results in understanding chromatin dynamics in cancer, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Skok, Jane Amanda — New York University School of Medicine
- Study coordinator: Skok, Jane Amanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.