How changes in certain amino acids affect heart function
Mechanisms Connecting Dysregulated Branched-Chain Alpha-Ketoacid Metabolism to Cardiac Dysfunction
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10880601
This study is looking at how certain amino acids might affect heart health in people with obesity and diabetes, and it hopes to find new ways to help improve heart function through changes in the liver.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10880601 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between branched-chain amino acids and cardiac dysfunction in conditions like obesity and diabetes. By studying animal models, the team aims to understand how manipulating specific enzymes related to these amino acids can impact heart health. The research focuses on the effects of liver-specific changes on heart function and aims to uncover the mechanisms behind these changes. Patients may benefit from new therapeutic strategies targeting these metabolic pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiometabolic diseases such as obesity, diabetes, or heart failure.
Not a fit: Patients without metabolic disorders or those with non-cardiometabolic related heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for heart dysfunction related to metabolic diseases.
How similar studies have performed: Previous research has shown promising results in manipulating metabolic pathways related to cardiac function, indicating potential for success in this approach.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCGARRAH, ROBERT WALKER — DUKE UNIVERSITY
- Study coordinator: MCGARRAH, ROBERT WALKER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Cardiometabolic Disease, Cardiometabolic Disorder