How changes in cell signaling affect aging and diseases like cancer and arthritis
Official title: Transcription Factor Network-Mediated Modulation of Transitional Senescence States
Funded at Rutgers Biomedical and Health Sciences · NIH-10941654 · Data updated 2026-11-12
This study is looking at how certain proteins that control our genes might affect aging and diseases like cancer and osteoarthritis, with the hope of finding new ways to help people stay healthier as they get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $336,070 |
| NIH project number | 1R35GM155447-01 |
| Project ID | NIH-10941654 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing age-related conditions, such as osteoarthritis or cancer.
✕Less likely to help
Patients with acute, non-degenerative conditions or those not affected by aging-related diseases may not benefit from this research.
What this research studies
This research investigates how transcription factors, which are proteins that help control the activity of genes, influence the aging process and the development of diseases such as cancer and osteoarthritis. By examining how these factors can change in response to various signals, the study aims to understand how cells can lose their identity and enter a state known as senescence, which is linked to aging and disease. The researchers will explore ways to manipulate these transitional states to potentially develop new therapies that could improve health outcomes for patients. This work involves advanced techniques to analyze cellular responses and could lead to significant insights into cell function and disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing aging-related diseases and improving overall health.
How similar studies have gone: Other research has shown promise in manipulating cellular states for therapeutic purposes, indicating that this approach could be viable.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Martinez Zamudio, Ricardo Ivan — Rutgers Biomedical and Health Sciences
- Study coordinator: Martinez Zamudio, Ricardo Ivan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.