How changes in cardiac troponin affect heart function
Impact of sequence changes on key intrinsically disordered regions of cardiac troponin
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11104045
This study is looking at how changes in a protein called cardiac troponin can affect how well your heart muscle contracts, which could help us find new ways to treat or prevent heart problems like cardiomyopathy and heart failure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11104045 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms by which changes in the sequence of cardiac troponin can impact heart muscle contraction. By examining the structure and function of troponin, particularly its intrinsically disordered regions, the study aims to understand how mutations can lead to conditions like cardiomyopathy and heart failure. The approach involves advanced biophysical techniques to analyze the interactions of troponin with other proteins in the heart. Patients may benefit from insights that could lead to new treatments or preventative strategies for heart diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of cardiomyopathy or those diagnosed with heart failure linked to genetic mutations.
Not a fit: Patients with heart conditions unrelated to troponin mutations may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with heart diseases related to troponin mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of troponin mutations in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREENBERG, MICHAEL J — WASHINGTON UNIVERSITY
- Study coordinator: GREENBERG, MICHAEL J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.