How changes in cardiac troponin affect heart function
Official title: Impact of sequence changes on key intrinsically disordered regions of cardiac troponin
Funded at Washington University · NIH-11104045 · Data updated 2026-11-12
This study is looking at how changes in a protein called cardiac troponin can affect how well your heart muscle contracts, which could help us find new ways to treat or prevent heart problems like cardiomyopathy and heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | June 4, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $776,791 |
| NIH project number | 1R01HL179124-01 |
| Project ID | NIH-11104045 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of cardiomyopathy or those diagnosed with heart failure linked to genetic mutations.
✕Less likely to help
Patients with heart conditions unrelated to troponin mutations may not receive direct benefits from this research.
What this research studies
This research investigates the molecular mechanisms by which changes in the sequence of cardiac troponin can impact heart muscle contraction. By examining the structure and function of troponin, particularly its intrinsically disordered regions, the study aims to understand how mutations can lead to conditions like cardiomyopathy and heart failure. The approach involves advanced biophysical techniques to analyze the interactions of troponin with other proteins in the heart. Patients may benefit from insights that could lead to new treatments or preventative strategies for heart diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with heart diseases related to troponin mutations.
How similar studies have gone: Previous research has shown promising results in understanding the role of troponin mutations in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Greenberg, Michael J — Washington University
- Study coordinator: Greenberg, Michael J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.