How changes in brain genes affect cocaine cravings
Official title: Chromatin regulation of BDNF in cocaine craving
Funded at Duke University · NIH-10993959 · Data updated 2026-11-12
This study is looking into why some people still crave cocaine even after they stop using it, by exploring how changes in brain genes might play a role, which could help us understand the lasting effects of cocaine addiction.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,236 |
| NIH project number | 1R21DA061547-01 |
| Project ID | NIH-10993959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of cocaine use who are currently abstinent but still experience cravings.
✕Less likely to help
Patients who have never used cocaine or those with other substance use disorders unrelated to cocaine may not benefit from this research.
What this research studies
This research investigates the biological mechanisms behind persistent cravings for cocaine even after stopping its use. It focuses on how changes in gene expression, particularly in dopamine neurons of the brain, contribute to these cravings. By using advanced molecular genetic techniques, the study aims to establish a direct link between chromatin regulation and drug-seeking behaviors. This could help in understanding the long-lasting effects of cocaine addiction on the brain.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help individuals overcome cocaine cravings and reduce the risk of relapse.
How similar studies have gone: Previous research has shown promising results in understanding the genetic and epigenetic factors involved in addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: West, Anne Elizabeth — Duke University
- Study coordinator: West, Anne Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.