How changes in brain cells affect alcohol use disorders
Chromatin remodeling in GABA neurons contributes to alcohol use disorder
This study is looking at how changes in brain cells called GABA neurons affect alcohol use and tolerance, with the hope of finding new ways to help people struggling with alcohol use disorder.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10788427 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin remodeling in GABA neurons and how it contributes to alcohol use disorder. By examining the genetic changes in these neurons after alcohol exposure, the study aims to understand the mechanisms behind alcohol tolerance and sedation. The approach includes advanced techniques like ATAC-seq to analyze chromatin accessibility and gene expression. The goal is to identify specific neuronal pathways and subtypes that could be targeted for new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who struggle with alcohol use disorder or have a history of high alcohol consumption.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating alcohol use disorders.
How similar studies have performed: Other research has shown promising results in understanding the genetic factors of alcohol use disorders, making this approach both relevant and potentially impactful.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Merrill, Collin — University of Utah
- Study coordinator: Merrill, Collin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.