How changes in blood vessel lining contribute to trauma-related complications
Official title: Alterations to endothelial membrane composition and structure as a driver of the endotheliopathy of trauma
Funded at Tulane University of Louisiana · NIH-11129913 · Data updated 2026-11-12
This study is looking at how serious injuries and blood loss can harm a protective layer on blood vessels, which might lead to problems like organ failure and blood clotting issues, and it aims to find ways to help trauma patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | July 10, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $328,950 |
| NIH project number | 5R01GM151631-02 |
| Project ID | NIH-11129913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are trauma patients who have experienced severe hemorrhage and are at risk for complications related to endothelial dysfunction.
✕Less likely to help
Patients who have not experienced trauma or severe hemorrhage may not benefit from this research.
What this research studies
This research investigates the damage to the endothelial glycocalyx, a protective layer on blood vessels, that occurs during severe trauma and hemorrhage. By examining how this damage leads to complications such as multi-organ failure and coagulopathy, the study aims to uncover the underlying mechanisms that drive these issues. The researchers will explore the role of metabolic processes and reactive oxygen species in the shedding of the glycocalyx, using both cell culture models and animal studies to gather data. This work could provide insights into potential therapeutic targets for improving outcomes in trauma patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce complications and improve survival rates for trauma patients experiencing severe hemorrhage.
How similar studies have gone: Previous research has indicated that targeting endothelial dysfunction can improve outcomes in trauma patients, suggesting that this approach may hold promise.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Jackson-Weaver, Olan — Tulane University of Louisiana
- Study coordinator: Jackson-Weaver, Olan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.