How changes in a specific protein affect heart muscle growth and function
Official title: Regulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophy
Funded at Ohio State University · NIH-11101142 · Data updated 2026-11-12
This study is looking at how certain proteins in heart muscle cells can help them grow in a healthy way or cause problems, with the goal of finding new treatments to keep your heart strong and prevent heart failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | May 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL157684-04 |
| Project ID | NIH-11101142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for heart failure or those with early signs of cardiac hypertrophy.
✕Less likely to help
Patients with advanced heart failure or those who do not have any cardiac conditions may not benefit from this research.
What this research studies
This research investigates the mechanisms behind heart muscle cell growth, particularly how certain proteins influence whether this growth is beneficial or harmful. By focusing on the phosphorylation of the STAT3 protein, the study aims to understand how heart cells adapt to stress and how this adaptation can prevent heart failure. The approach includes examining cellular responses to stress and testing potential interventions that could help maintain healthy heart function. Patients may benefit from insights that could lead to new treatments for heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent heart failure by promoting healthy heart muscle growth.
How similar studies have gone: Other research has shown promise in understanding cardiac hypertrophy, but this specific approach focusing on STAT3 phosphorylation is relatively novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Nassal, Drew — Ohio State University
- Study coordinator: Nassal, Drew
Related research
Other NIH-funded projects on the same topics.
-
Understanding how trinucleotide repeat expansions cause disease
A research project at Ohio State University is exploring how tiny DNA repeats become unstable and drive neurological and muscular diseases, with potential implications for future therapies.
-
Pediatric Prehospital Airway Resuscitation for Critically Ill Children
This grant tests the best way for paramedics to manage breathing tubes and other airways in seriously ill children before they reach the hospital.
-
From Social Breakups to Brain Changes in Alzheimer’s and Related Dementias
This grant explores how losing social connections may trigger brain changes and inflammation linked to Alzheimer’s disease and related dementias.
-
Understanding why patients with blood cancers start and stick with oral cancer medicines
A study to learn what helps or hinders Black patients with blood cancers in starting and continuing their prescribed oral cancer medicines.
-
How sex and hormones affect alcohol's impact on sleep in adults
This study tests how sex and hormone changes influence how alcohol disrupts sleep in healthy adults, with a focus on women aged 21-45.
-
Natural products to block IL-8 signaling and prevent Barrett's Esophagus from turning into esophageal cancer
A搜索-friendly plan to use safe natural compounds to interrupt a key inflammatory signal (IL-8) and stop Barrett’s esophagus from turning into esophageal cancer in people with GERD.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.