How changes in a specific protein affect heart muscle growth and function
Regulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophy
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-11101142
This study is looking at how certain proteins in heart muscle cells can help them grow in a healthy way or cause problems, with the goal of finding new treatments to keep your heart strong and prevent heart failure.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11101142 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind heart muscle cell growth, particularly how certain proteins influence whether this growth is beneficial or harmful. By focusing on the phosphorylation of the STAT3 protein, the study aims to understand how heart cells adapt to stress and how this adaptation can prevent heart failure. The approach includes examining cellular responses to stress and testing potential interventions that could help maintain healthy heart function. Patients may benefit from insights that could lead to new treatments for heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for heart failure or those with early signs of cardiac hypertrophy.
Not a fit: Patients with advanced heart failure or those who do not have any cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent heart failure by promoting healthy heart muscle growth.
How similar studies have performed: Other research has shown promise in understanding cardiac hypertrophy, but this specific approach focusing on STAT3 phosphorylation is relatively novel.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NASSAL, DREW — OHIO STATE UNIVERSITY
- Study coordinator: NASSAL, DREW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers