How changes in a key protein affect the behavior of a harmful gut bacteria.
Variations in a master regulator affects Clostridioides difficile physiology and virulence
This study is looking at how changes in a specific protein affect the behavior of Clostridioides difficile, the bacteria that can lead to serious gut infections, especially after antibiotics upset the balance of good bacteria in your intestines.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kansas State University NIH-funded |
| Lab location | 1 site (Manhattan, United States) |
| Project ID | NIH-10645086 on NIH RePORTER |
What this research studies
This research investigates how variations in a master regulator protein influence the physiology and virulence of Clostridioides difficile, a bacteria that can cause severe intestinal infections. By examining how this protein interacts with nutrients and regulates toxin production, the study aims to understand the mechanisms that allow C. difficile to thrive, especially after antibiotic use disrupts normal gut flora. The research employs genetic analysis and biological assays to identify mutations in the codY gene that may affect the bacteria's ability to cause disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced recurrent Clostridioides difficile infections or are at high risk due to antibiotic use.
Not a fit: Patients who do not have a history of Clostridioides difficile infections or are not at risk due to antibiotic use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections caused by Clostridioides difficile.
How similar studies have performed: Other research has shown success in understanding bacterial virulence through genetic mutations, indicating that this approach has potential for meaningful insights.
Where this research is happening
Manhattan, United States
- Kansas State University — Manhattan, United States (Active)
Researchers
- Principal investigator: Govind, Revathi — Kansas State University
- Study coordinator: Govind, Revathi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.