How cetylpyridinium chloride affects immune cell function
Official title: Mechanisms of cetylpyridinium chloride inhibition of immune cell function
Funded at University of Maine Orono · NIH-10513855 · Data updated 2026-11-12
This study is looking at how a common antibacterial ingredient called cetylpyridinium chloride (CPC) affects immune cells in your body, especially in your mouth, to see if it might cause any harm to your health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maine Orono NIH-funded |
| Lab location | 1 site (Orono, United States) |
| Project start | August 11, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $426,405 |
| NIH project number | 1R15ES034567-01 |
| Project ID | NIH-10513855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who frequently use products containing cetylpyridinium chloride, such as mouthwashes or certain personal care items.
✕Less likely to help
Patients who do not use products containing cetylpyridinium chloride or have no exposure to it may not benefit from this research.
What this research studies
This research investigates the effects of cetylpyridinium chloride (CPC), a common antibacterial agent found in various products, on immune cell function. The study focuses on how low concentrations of CPC can inhibit the signaling processes in mast cells and T cells, which are crucial for immune responses. By examining the biochemical pathways involved, the research aims to understand the potential toxicological effects of CPC on human health, particularly in the oral environment where it is frequently encountered. The approach includes laboratory experiments to analyze the cellular responses of these immune cells when exposed to CPC.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how common antibacterial agents like CPC affect immune health, potentially guiding safer product formulations.
How similar studies have gone: While there is limited research specifically on CPC's effects on immune cells, similar studies on other antibacterial agents have shown significant impacts on immune function.
Where this research is happening
-
University of Maine Orono
Orono, United States Active
Researchers
- Principal investigator: Gosse, Julie Ann — University of Maine Orono
- Study coordinator: Gosse, Julie Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.