How certain X-linked genes control X chromosome silencing
X-chromosome Inactivation Catalyzed by Genes that Escape X-inactivation
This project looks at how higher amounts of an X-linked gene called KDM5C can change whether an X chromosome gets turned off and how that may cause sex differences in gene activity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11237075 on NIH RePORTER |
What this research studies
If you are interested in how biological sex shapes genes, researchers will change KDM5C levels in embryonic stem cells and related cell models to see how that affects X chromosome inactivation. They will measure gene activity and chromatin (DNA packaging) changes and compare effects at different gene doses. The team will use molecular tools and genomic readouts to track both X-linked and autosomal gene expression in male and female contexts. Findings will clarify the cellular steps by which KDM5C produces sex-biased gene regulation.
Who could benefit from this research
Good fit: This is primarily a lab-based basic research project and does not enroll patients, though people interested in contributing tissue or samples related to X-linked disorders might be relevant in future related studies.
Not a fit: Patients seeking immediate therapies should not expect direct medical benefit from this basic science project because it focuses on cellular mechanisms rather than clinical treatment.
Why it matters
Potential benefit: Understanding this mechanism could explain why some conditions differ between sexes and point to molecular targets to correct harmful sex-biased gene expression.
How similar studies have performed: Earlier work from this group and others has shown KDM5C influences X-inactivation in model systems, so the proposal builds on promising preliminary data rather than an entirely untested idea.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Kalantry, Sundeep — University of Michigan at Ann Arbor
- Study coordinator: Kalantry, Sundeep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.