How certain steroids affect the size of blood vessels
Regulation of arterial diameter through specific sensing of endogenous steroids and novel nonsteroidal analogs by BK channel subunits
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-10364605
This study is looking at how natural hormones in your body can change the size of blood vessels in a new way, which could help us find better treatments for conditions that affect blood flow.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10364605 on ClinicalTrials.gov |
What this research studies
This research investigates how endogenous steroids, which are hormones produced by the body, can directly influence the diameter of blood vessels without relying on traditional steroid receptors. The study focuses on specific interactions between these steroids and ion channel proteins in smooth muscle cells, using advanced techniques like computational modeling and patch-clamp recordings. By examining genetically engineered mice and various types of arteries, the research aims to uncover new mechanisms of vascular regulation that could lead to improved treatments for blood flow-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting blood vessel function, such as hypertension or vascular diseases.
Not a fit: Patients who do not have vascular issues or related hormonal imbalances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing conditions related to blood vessel function and circulation.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that understanding steroid interactions with ion channels can lead to significant advancements in vascular biology.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOPICO, ALEX M. — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: DOPICO, ALEX M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.