How certain skin nerves affect immune responses in the skin
Epidermal Nonpeptidergic Nerves Modulate Cutaneous Immunity
This study is looking at special nerve cells in the skin and how they work with immune cells to help protect against inflammation and skin issues, which could lead to new treatments for better skin health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10887560 on NIH RePORTER |
What this research studies
This research investigates the role of nonpeptidergic sensory neurons in the skin and their interaction with immune cells. By analyzing different subsets of these neurons, the study aims to understand how they contribute to skin immunity and inflammation. The researchers will utilize advanced techniques like single-cell RNA sequencing to identify the specific functions of these neuron subsets. This knowledge could lead to new treatments that target these neurons to improve immune responses in the skin.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with allergic skin conditions or those experiencing chronic skin inflammation.
Not a fit: Patients with non-allergic skin conditions or those not experiencing immune-related skin issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance skin immunity and treat allergic diseases more effectively.
How similar studies have performed: Previous research has shown promising results in understanding the role of sensory neurons in immune responses, indicating that this approach has potential for success.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Kaplan, Daniel H — University of Pittsburgh at Pittsburgh
- Study coordinator: Kaplan, Daniel H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.