How certain signals and genes affect pancreas development and diabetes.
Intersection of signaling pathways and transcription factors regulating islet development
This study is looking at how certain genes, especially the GATA6 gene, affect the development of the pancreas and how this might relate to diabetes, with the hope of finding new ways to help people manage their condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11001490 on NIH RePORTER |
What this research studies
This research investigates the role of specific signaling pathways and transcription factors in the development of the pancreas, particularly focusing on the GATA6 gene and its interaction with retinoic acid. By using advanced models, including human stem cells and mice, the researchers aim to understand how these factors contribute to conditions like pancreas agenesis and adult-onset diabetes. The study seeks to uncover the genetic mechanisms that lead to varying degrees of diabetes severity in individuals with GATA6 mutations, potentially leading to new insights into diabetes management.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of pancreas agenesis or adult-onset diabetes, particularly those with known GATA6 mutations.
Not a fit: Patients without any genetic predisposition to pancreas agenesis or adult-onset diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with adult-onset diabetes linked to genetic factors.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors influencing pancreas development, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Gadue, Paul J — Children's Hosp of Philadelphia
- Study coordinator: Gadue, Paul J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.