How certain receptors affect brain signaling related to mood and behavior
Official title: Regulation of monoamine neurons by delta glutamate receptors
Funded at University of Iowa · NIH-11052640 · Data updated 2026-11-12
This study is looking at how certain receptors in the brain affect mood and behavior, which could help us understand and improve treatments for conditions like depression and anxiety.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $502,403 |
| NIH project number | 5R37DA060149-02 |
| Project ID | NIH-11052640 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with mood disorders or substance use disorders who are seeking new treatment options.
✕Less likely to help
Patients with purely physical health conditions unrelated to neuropsychiatric issues may not receive any benefit from this research.
What this research studies
This research investigates the role of delta glutamate receptors in regulating the activity of monoamine neurons, which are crucial for mood and behavior. By examining how these receptors interact with ion channels and influence neurotransmitter release, the study aims to fill a significant knowledge gap in understanding neuropsychiatric disorders. Patients may benefit from insights gained about the mechanisms underlying conditions like depression and anxiety, potentially leading to new treatment strategies. The research employs advanced techniques to analyze neuronal signaling pathways and their effects on brain function.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating neuropsychiatric and substance use disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of glutamate receptors in brain signaling, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Gantz, Stephanie C. — University of Iowa
- Study coordinator: Gantz, Stephanie C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.