How certain proteins influence organ development and disease
Oocyte polarity and BMP-mediated dorsoventral patterning
This study is looking at how certain proteins help organs and tissues grow, using zebrafish to learn more about how these proteins work together, which could lead to better treatments for various health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11074640 on NIH RePORTER |
What this research studies
This research investigates the role of Bone Morphogenetic Proteins (BMPs) in the development of various organs and tissues, focusing on how BMP heterodimers signal more effectively than homodimers. By using zebrafish as a model organism, the research aims to understand the specific functions of BMP Type I receptors in signaling pathways that affect organ development and contribute to diseases. The findings could enhance the application of BMPs in medical fields such as tissue engineering and regenerative medicine, potentially leading to improved treatments for congenital and adult diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital or adult diseases related to BMP signaling, such as cardiovascular or kidney conditions.
Not a fit: Patients with conditions unrelated to BMP signaling or those who are not affected by congenital or adult diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better therapeutic strategies for conditions like cardiovascular defects and kidney disease.
How similar studies have performed: Previous research has shown promising results in understanding BMP signaling, indicating that this approach has potential for significant advancements in medical applications.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mullins, Mary C. — University of Pennsylvania
- Study coordinator: Mullins, Mary C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.