How certain proteins influence cell shape changes in the brain and cancer cells
Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape Change
This study is looking at how two proteins, TRIM9 and TRIM67, help cells change shape, which is important for brain development and cancer spread, and the findings could help us understand and improve treatments for conditions like cancer and neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11010938 on NIH RePORTER |
What this research studies
This research investigates the roles of specific proteins, TRIM9 and TRIM67, in how cells change shape, particularly in developing neurons and cancer cells. By examining the interactions between these proteins and the cellular structures that guide movement and shape, the research aims to uncover mechanisms that could affect brain development and cancer metastasis. The approach involves studying how these proteins regulate the cytoskeleton and membrane dynamics in response to external signals. Patients may benefit from insights gained about cellular behavior in diseases like cancer and neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or cancers, particularly melanoma.
Not a fit: Patients with conditions unrelated to brain function or cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating brain disorders and cancer by targeting the mechanisms of cell shape change.
How similar studies have performed: Previous research has shown promising results in understanding the roles of E3 ubiquitin ligases in cellular processes, indicating potential for success in this innovative approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Gupton, Stephanie — Univ of North Carolina Chapel Hill
- Study coordinator: Gupton, Stephanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.