How certain proteins help control pain and blood clotting
Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteins
This study is looking at special proteins that help control pain and blood clotting, hoping to find new ways to manage pain and improve treatments for blood disorders, which could help patients like you feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10762471 on NIH RePORTER |
What this research studies
This research investigates the role of TMEM16 proteins, which are involved in various cellular processes such as pain control and blood coagulation. By studying how these proteins function as ion channels and lipid scramblases, the research aims to uncover their mechanisms in regulating pain and inflammation. The approach includes advanced techniques like mutagenesis screens and electrophysiology to analyze the proteins' properties and structures. Patients may benefit from a better understanding of pain management and treatment options related to blood clotting disorders.
Who could benefit from this research
Good fit: Ideal candidates include individuals suffering from chronic pain conditions or blood coagulation disorders.
Not a fit: Patients with conditions unrelated to pain management or blood coagulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for pain management and blood coagulation disorders.
How similar studies have performed: Previous research has shown promise in understanding the roles of TMEM16 proteins, indicating potential for significant advancements in related areas.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Grabe, Michael — University of California, San Francisco
- Study coordinator: Grabe, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.