How certain proteins help control gene activity
The Positive Roles of Lysine Deacetylase Complexes in Regulating Transcriptional Dynamics
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-10982721
This study is looking at how certain proteins help control gene activity when our bodies respond to hormones, which could help us understand diseases linked to these processes and improve treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-10982721 on ClinicalTrials.gov |
What this research studies
This research investigates the role of lysine deacetylase complexes in regulating how genes are activated or repressed, particularly in response to glucocorticoid signaling. By studying these complexes, the research aims to uncover the mechanisms that allow these proteins to promote gene transcription in specific contexts. Patients may benefit from understanding how these processes affect various diseases, especially those related to hormonal signaling and gene regulation. The research employs advanced biological assays to analyze the interactions and functions of these proteins in cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to hormonal imbalances or gene regulation disorders.
Not a fit: Patients with conditions unrelated to gene regulation or hormonal signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for diseases influenced by hormonal signaling.
How similar studies have performed: Other research has shown promising results in understanding the roles of similar protein complexes in gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMITH, CATHARINE LYNN — UNIVERSITY OF ARIZONA
- Study coordinator: SMITH, CATHARINE LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.