How certain proteins are regulated by chemical modifications and inhibitors
Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors
This study is looking at how certain proteins that help process medications in the body are influenced by specific changes, which could lead to better and more effective drug treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11100469 on NIH RePORTER |
What this research studies
This research investigates the regulation of specific proteins, OATP1B1 and OATP1B3, which play crucial roles in drug metabolism and transport. By examining how these proteins are affected by lysine acetylation and the use of lysine deacetylase inhibitors, the research aims to enhance our understanding of drug interactions and efficacy. The study employs advanced automated protein analysis techniques to ensure high sensitivity and reproducibility in its findings. Patients may benefit from improved drug therapies as a result of this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing treatment with drugs that are metabolized by OATP1B1 and OATP1B3.
Not a fit: Patients who are not taking medications affected by these specific proteins may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective drug therapies with fewer adverse effects for patients.
How similar studies have performed: Other research has shown promising results in understanding protein regulation and its impact on drug metabolism, indicating that this approach has potential for success.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Yue, Wei — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Yue, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.