How certain proteins affect the immune response in inflammatory bowel disease
Official title: Control by Beta 7 integrins of the bacterial triggers of IBD
Funded at VA San Diego Healthcare System · NIH-11098441 · Data updated 2026-11-12
This study is looking at how a specific protein called beta 7 integrin affects the immune system in people with inflammatory bowel disease (IBD) by using specially modified mice, with the goal of finding better ways to treat IBD.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX005951-03 |
| Project ID | NIH-11098441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those who may not respond well to current therapies.
✕Less likely to help
Patients with non-inflammatory bowel conditions or those who are not diagnosed with IBD may not benefit from this research.
What this research studies
This research investigates the role of beta 7 integrins in the immune response related to inflammatory bowel disease (IBD). It explores how these proteins influence the behavior and function of B cells, which are crucial for immune responses. By using genetically modified mice, the study examines the effects of beta 7 integrin deficiency on the development and severity of IBD. The findings aim to enhance our understanding of IBD and potentially improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with inflammatory bowel disease.
How similar studies have gone: Previous research has shown that targeting integrins can be effective in treating IBD, indicating a promising avenue for further exploration.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Rivera-Nieves, Jesus — VA San Diego Healthcare System
- Study coordinator: Rivera-Nieves, Jesus
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.