How certain proteins affect the immune response in inflammatory bowel disease
Control by Beta 7 integrins of the bacterial triggers of IBD
This study is looking at how a specific protein called beta 7 integrin affects the immune system in people with inflammatory bowel disease (IBD) by using specially modified mice, with the goal of finding better ways to treat IBD.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-11098441 on NIH RePORTER |
What this research studies
This research investigates the role of beta 7 integrins in the immune response related to inflammatory bowel disease (IBD). It explores how these proteins influence the behavior and function of B cells, which are crucial for immune responses. By using genetically modified mice, the study examines the effects of beta 7 integrin deficiency on the development and severity of IBD. The findings aim to enhance our understanding of IBD and potentially improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, particularly those who may not respond well to current therapies.
Not a fit: Patients with non-inflammatory bowel conditions or those who are not diagnosed with IBD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with inflammatory bowel disease.
How similar studies have performed: Previous research has shown that targeting integrins can be effective in treating IBD, indicating a promising avenue for further exploration.
Where this research is happening
San Diego, United States
- VA San Diego Healthcare System — San Diego, United States (Active)
Researchers
- Principal investigator: Rivera-Nieves, Jesus — VA San Diego Healthcare System
- Study coordinator: Rivera-Nieves, Jesus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.