How certain proteins affect the growth of the uterine lining and female fertility
Official title: Regulation of endometrial proliferation by the PGRMC family
Funded at University of Wyoming · NIH-11059196 · Data updated 2026-11-12
This study is looking at how certain proteins in the body might affect women's fertility and the health of the uterus, which could help us understand fertility issues and find new treatments for conditions like endometrial cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wyoming NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project start | April 15, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $325,125 |
| NIH project number | 5R01HD102386-05 |
| Project ID | NIH-11059196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include women experiencing fertility issues or those diagnosed with endometrial cancer.
✕Less likely to help
Patients with unrelated reproductive health issues or those not affected by endometrial conditions may not benefit from this research.
What this research studies
This research investigates the role of progesterone receptor membrane components (PGRMC1 and PGRMC2) in female fertility and endometrial health. By studying genetically modified mice, the researchers aim to understand how these proteins influence the proliferation of endometrial cells, particularly during the menstrual cycle. The study also explores the connection between these proteins and endometrial cancer, including how they may affect tumor growth and response to chemotherapy. Patients may benefit from insights into fertility issues and potential new treatments for endometrial conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for women facing fertility challenges and endometrial cancer.
How similar studies have gone: Other research has shown promising results in understanding the role of hormonal receptors in reproductive health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wyoming
Laramie, United States Active
Researchers
- Principal investigator: Pru, James K — University of Wyoming
- Study coordinator: Pru, James K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.