How certain proteins affect the growth of brain cancer cells
Interaction between Tissue Factor, Junctional Adhesion Molecule-A, and Integrin B1 to drive self-renewal in glioblastoma
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10832969
This study is looking at how certain proteins help cancer stem cells survive and grow in glioblastoma, a tough type of brain cancer, to find new ways to treat patients like you more effectively.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10832969 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins, Tissue Factor and Junctional Adhesion Molecule-A, in the survival and growth of cancer stem cells in glioblastoma, a deadly brain cancer. By understanding how these proteins interact and promote the self-renewal of these resistant cancer cells, the research aims to identify new therapeutic targets. The approach involves analyzing the effects of inhibiting these proteins on tumor growth and recurrence in laboratory models. If successful, this could lead to more effective treatments for patients with glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma, particularly those who have undergone treatment but are at risk of tumor recurrence.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with glioblastoma by targeting cancer stem cells.
How similar studies have performed: Other research has shown promising results in targeting cancer stem cells in glioblastoma, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HORBINSKI, CRAIG MICHAEL — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: HORBINSKI, CRAIG MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.