How certain proteins affect RNA during development and disease
ERK-mediated regulation of non-coding RNAs during development and disease
['FUNDING_OTHER'] · UNIVERSITY OF TX MD ANDERSON CAN CTR · NIH-10893374
This study is looking at how certain proteins help control important molecules that are key for early development in embryos, using tiny worms called C. elegans, to learn more about how these proteins affect the production and breakdown of RNA during a specific stage in egg cells, which could help us understand more about reproductive health and developmental issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TX MD ANDERSON CAN CTR (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10893374 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins in regulating non-coding RNAs, which are crucial for early embryonic development. By studying the model organism C. elegans, the researchers aim to understand how these proteins influence RNA production and degradation during the long period of meiotic arrest in oocytes. The study employs advanced techniques, including CRISPR, to manipulate these proteins and observe their effects on RNA dynamics. The findings could provide insights into reproductive health and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing reproductive challenges or those interested in the genetic factors affecting embryonic development.
Not a fit: Patients not facing reproductive issues or those with unrelated genetic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for reproductive issues and developmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding RNA regulation in similar contexts, indicating that this approach has potential for success.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TX MD ANDERSON CAN CTR — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARUR, SWATHI — UNIVERSITY OF TX MD ANDERSON CAN CTR
- Study coordinator: ARUR, SWATHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.