How certain proteins affect hormone receptor activity in breast and prostate cancers.
Mechanisms by which histone methyltransferases regulate nuclear receptor activity and response to therapy in hormone-driven tumors.
This study is looking at how certain proteins affect hormone activity in breast and prostate cancers, especially how changes in a specific signaling pathway might impact tumor growth and treatment responses, with the goal of finding better ways to help patients with hormone-related tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11043231 on NIH RePORTER |
What this research studies
This research investigates the role of histone methyltransferases in regulating hormone receptor activity in breast and prostate cancers. It focuses on how alterations in the PI3K signaling pathway influence tumor growth and response to therapies. By examining the interactions between these proteins and hormone receptors, the study aims to uncover mechanisms that could lead to improved treatment strategies for patients with hormone-driven tumors. The research utilizes advanced cancer models and patient-derived organoids to explore these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced breast or prostate cancer, particularly those with alterations in the PI3K pathway.
Not a fit: Patients with non-hormone-driven tumors or those without alterations in the PI3K pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with hormone-driven cancers, improving treatment outcomes.
How similar studies have performed: Other research has shown promising results in targeting the PI3K pathway in hormone-driven cancers, indicating that this approach has potential for success.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Toska, Eneda — Johns Hopkins University
- Study coordinator: Toska, Eneda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.