How certain proteins affect hormone receptor activity in breast and prostate cancers.
Official title: Mechanisms by which histone methyltransferases regulate nuclear receptor activity and response to therapy in hormone-driven tumors.
Funded at Johns Hopkins University · NIH-11043231 · Data updated 2026-11-12
This study is looking at how certain proteins affect hormone activity in breast and prostate cancers, especially how changes in a specific signaling pathway might impact tumor growth and treatment responses, with the goal of finding better ways to help patients with hormone-related tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 16, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $374,578 |
| NIH project number | 5R01CA276187-03 |
| Project ID | NIH-11043231 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with advanced breast or prostate cancer, particularly those with alterations in the PI3K pathway.
✕Less likely to help
Patients with non-hormone-driven tumors or those without alterations in the PI3K pathway may not benefit from this research.
What this research studies
This research investigates the role of histone methyltransferases in regulating hormone receptor activity in breast and prostate cancers. It focuses on how alterations in the PI3K signaling pathway influence tumor growth and response to therapies. By examining the interactions between these proteins and hormone receptors, the study aims to uncover mechanisms that could lead to improved treatment strategies for patients with hormone-driven tumors. The research utilizes advanced cancer models and patient-derived organoids to explore these interactions.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with hormone-driven cancers, improving treatment outcomes.
How similar studies have gone: Other research has shown promising results in targeting the PI3K pathway in hormone-driven cancers, indicating that this approach has potential for success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Toska, Eneda — Johns Hopkins University
- Study coordinator: Toska, Eneda
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.