How certain proteins affect gut development and related diseases
Dependence for TEAD transcription factors in intestinal development and polyposis
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-10896334
This study is looking at how certain proteins help shape the gut and how problems with these proteins might be linked to digestive diseases and cancers, with the hope that understanding these processes can lead to better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10896334 on ClinicalTrials.gov |
What this research studies
This research investigates the role of TEAD transcription factors in the development of the gastrointestinal (GI) tract and their potential link to digestive diseases and cancers. By studying the interactions between different cell types during gut formation, the research aims to uncover the genetic and molecular mechanisms that govern mesenchymal growth and differentiation. The approach involves analyzing how Hippo/YAP signaling influences these processes, which could lead to new therapeutic strategies for GI disorders. Patients may benefit from insights gained into the underlying causes of their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal diseases or those at risk for related cancers.
Not a fit: Patients with non-gastrointestinal conditions or those not affected by digestive diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for gastrointestinal diseases and cancers.
How similar studies have performed: Previous research has shown promising results in understanding the role of signaling pathways in organ development, suggesting potential for success in this area as well.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAO, JUNHAO — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: MAO, JUNHAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amplified in Breast Cancer 1, Amplified in Breast Cancer 1 Protein