How certain proteins adapt to extreme environments and their potential as drug targets
The Regulation of Inteins: Adaptations in Extremophiles and Targets for Drug Discovery
['FUNDING_R15'] · COLLEGE OF THE HOLY CROSS · NIH-10874997
This study is looking at special proteins called inteins that can remove themselves from other proteins, focusing on how these proteins from tough organisms survive in extreme conditions, and it aims to find new ways to use this knowledge for developing drugs that could help control certain bacteria.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLLEGE OF THE HOLY CROSS (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-10874997 on ClinicalTrials.gov |
What this research studies
This research investigates inteins, which are unique proteins that can remove themselves from other proteins through a process called protein splicing. The study focuses on how these inteins from extremophiles, organisms that thrive in extreme conditions, adapt to their harsh environments. By using various laboratory techniques, including enzymology and genetic manipulation, researchers aim to understand the role of inteins in their host organisms and explore their potential as targets for new drug development. The research also seeks to identify small molecules that can inhibit the function of these inteins, which could have implications for controlling the growth of certain bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with infections caused by bacteria that may be influenced by intein activity.
Not a fit: Patients with conditions unrelated to bacterial infections or those not affected by intein-related mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drugs that target specific proteins involved in bacterial growth, potentially improving treatment options for infections.
How similar studies have performed: While the study of inteins is a relatively novel area, there have been successful applications of similar approaches in understanding protein functions and developing targeted therapies.
Where this research is happening
WORCESTER, UNITED STATES
- COLLEGE OF THE HOLY CROSS — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLS, KENNETH V — COLLEGE OF THE HOLY CROSS
- Study coordinator: MILLS, KENNETH V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.