How certain protein complexes influence gene activation in breast cancer
Mechanisms of RING1B and PRC1 complexes in transcriptional activation
This study is looking at how a protein called PRC1 affects gene activity in breast cancer cells, especially how it can both turn genes off and on when estrogen is present, which could help us understand more about how breast cancer grows and how to treat it better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11012293 on NIH RePORTER |
What this research studies
This research investigates the role of Polycomb Repressive Complex 1 (PRC1) in regulating gene expression, particularly in breast cancer cells. It explores how PRC1, traditionally known for repressing genes, can also activate them in response to estrogen. By examining the interactions between PRC1 and the estrogen receptor, the study aims to uncover the mechanisms that control cell growth and fate decisions in cancer. Patients may benefit from insights into how these processes contribute to breast cancer progression and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those whose tumors may be influenced by hormonal factors.
Not a fit: Patients with non-hormone-responsive cancers or those not diagnosed with breast cancer may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting gene regulation in breast cancer.
How similar studies have performed: Previous research has shown that targeting epigenetic mechanisms can be effective in cancer treatment, indicating potential for success in this area as well.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Morey, Lluis — University of Miami School of Medicine
- Study coordinator: Morey, Lluis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.