How certain metabolites affect the growth of Pseudomonas aeruginosa
Official title: Cross-fed metabolites modulate Pseudomonas aeruginosa fitness
Funded at Dartmouth College · NIH-10899946 · Data updated 2026-11-12
This study is looking at how a protein called CbrA affects the way two germs, Pseudomonas aeruginosa and Candida albicans, interact when they infect people with cystic fibrosis, with the goal of finding better ways to manage these infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI179113-01A1 |
| Project ID | NIH-10899946 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with cystic fibrosis who are experiencing chronic infections with Pseudomonas aeruginosa and Candida albicans.
✕Less likely to help
Patients without cystic fibrosis or those not infected with Pseudomonas aeruginosa or Candida albicans may not benefit from this research.
What this research studies
This research investigates the interactions between Pseudomonas aeruginosa and Candida albicans, particularly in patients with cystic fibrosis. It focuses on understanding how a specific protein, CbrA, influences the behavior of these bacteria and fungi when they co-infect a patient. By using genetic and biochemical methods, the research aims to uncover the mechanisms that enhance the virulence of these pathogens, which could lead to worse health outcomes for patients. The findings may provide insights into how to better manage infections caused by these organisms.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with cystic fibrosis who are co-infected with Pseudomonas aeruginosa and Candida albicans.
How similar studies have gone: Previous research has shown promising results in understanding bacterial interactions, but this specific approach focusing on CbrA and its role in co-infections is relatively novel.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Conaway, Amy Carolyn — Dartmouth College
- Study coordinator: Conaway, Amy Carolyn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.