How certain lung cells help heal injuries in the lungs
p16INK4a+ fibroblasts regulate epithelial regeneration after injury in lung alveoli through the SASP
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11063318
This study is looking at how certain lung cells help heal lung injuries, especially as we age or face environmental challenges, using a special mouse model to see how these cells work in different parts of the lungs.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11063318 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific lung cells, known as p16INK4a+ fibroblasts, in the healing process after lung injuries. By using a special mouse model, researchers will explore how these cells contribute to the regeneration of lung tissue and whether their effects are limited to certain areas of the lungs. The study aims to understand the balance between the beneficial and detrimental roles of these cells in lung repair, particularly in the context of aging and environmental stressors.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced lung injuries or have conditions affecting lung function.
Not a fit: Patients with non-lung related injuries or conditions that do not involve epithelial regeneration in the lungs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung healing and regeneration in patients with lung injuries or diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of senescent cells in tissue regeneration, suggesting that this approach may yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REYES DE BARBOZA, NABORA SOLEDAD — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: REYES DE BARBOZA, NABORA SOLEDAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.