How certain liver proteins are regulated by chemical modifications
Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors
This study is looking at how certain liver proteins that help move medications into the liver are controlled, which could help doctors better understand how different drugs work together and their possible side effects, especially for people who take several medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10873782 on NIH RePORTER |
What this research studies
This research investigates how specific liver proteins, known as OATP1B1 and OATP1B3, are regulated by a process called lysine acetylation. These proteins play a crucial role in transporting various drugs and toxins into the liver, which can affect how medications work and their potential side effects. By understanding the molecular mechanisms that control these proteins, the research aims to improve predictions of drug interactions and adverse effects, particularly for patients taking multiple medications. The study will involve laboratory experiments to explore how changes in acetylation influence the function of these transport proteins.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients who are taking multiple medications, especially those involving statins or anticancer agents.
Not a fit: Patients who are not on any medications or those with conditions unrelated to drug metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer medication use by reducing the risk of adverse drug interactions.
How similar studies have performed: Previous research has shown that understanding the regulation of drug transport proteins can lead to significant advancements in predicting drug interactions, suggesting this approach has potential for success.
Where this research is happening
Oklahoma City, United States
- University of Oklahoma Hlth Sciences Ctr — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Yue, Wei — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Yue, Wei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.