How certain lipids affect bone cells in gum disease.
Mechanosensing of osteoclasts in periodontitis.
This study is looking at how a substance made by bacteria linked to gum disease affects bone cells that help with bone healing, aiming to find new ways to help people with periodontitis keep their bones healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nova Southeastern University NIH-funded |
| Lab location | 1 site (Fort Lauderdale-Davie, UNITED STATES) |
| Project ID | NIH-10923935 on NIH RePORTER |
What this research studies
This research investigates how a specific lipid produced by the bacteria associated with gum disease, Porphyromonas gingivalis, impacts bone cells called osteoclasts. The study aims to understand the molecular mechanisms by which this lipid inhibits the normal functioning of these cells, which are crucial for bone regeneration. By examining the interactions between the lipid and the Piezo1 mechanosensing system in osteoclasts, the researchers hope to uncover new insights into the processes that lead to bone loss in periodontitis. This could lead to better therapeutic strategies for patients suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with periodontitis, particularly those experiencing significant bone loss.
Not a fit: Patients without periodontitis or those with other unrelated dental conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance bone regeneration in patients with periodontitis.
How similar studies have performed: While the specific approach of targeting the mechanosensing system in osteoclasts is novel, similar research has shown promise in understanding the role of bacterial factors in periodontal disease.
Where this research is happening
Fort Lauderdale-Davie, UNITED STATES
- Nova Southeastern University — Fort Lauderdale-Davie, United States (Active)
Researchers
- Principal investigator: Shindo, Satoru — Nova Southeastern University
- Study coordinator: Shindo, Satoru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.