How certain immune cells help balance autoimmunity and pathogen defense
Regulation of central tolerance and Treg development by recirculating Treg
This study is looking at a special type of immune cell that helps keep your body from attacking itself while still fighting off infections, and it hopes to find ways to improve treatments for autoimmune diseases and boost your immune response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11076812 on NIH RePORTER |
What this research studies
This research investigates the role of a specific type of immune cell, known as recirculating Treg cells, in maintaining a balance between preventing autoimmune diseases and effectively responding to infections. The study aims to understand how these cells influence the development of other immune cells in the thymus, which is crucial for generating a diverse immune response. By examining the characteristics and functions of these Treg cells, the research seeks to uncover mechanisms that could improve immune system function and tolerance. Patients may benefit from insights that could lead to new treatments for autoimmune conditions and enhance immune responses to infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those interested in understanding their immune system's function.
Not a fit: Patients with no autoimmune conditions or those who are not interested in immune system research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for autoimmune diseases and better immune responses to infections.
How similar studies have performed: Previous research has shown promising results in understanding immune cell interactions, suggesting that this approach could yield significant insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Farrar, Michael Archibald — University of Minnesota
- Study coordinator: Farrar, Michael Archibald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.