How certain immune cells contribute to allergic lung inflammation after viral infections
IL-4-activated macrophages: Contribution to allergic lung inflammation linked to viral infection
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10532357
This study is looking at how certain immune cells in the body react to viruses in young kids, especially those who were born early or have lung issues, to better understand how these reactions can lead to asthma flare-ups and find ways to help prevent them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10532357 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific immune cells, known as macrophages, in the development of allergic asthma following viral infections in infants and children. It focuses on understanding how these cells become activated by viruses like rhinovirus and respiratory syncytial virus, particularly in those who were born prematurely or have chronic lung diseases. By studying the mechanisms of inflammation and immune response, the research aims to uncover potential therapeutic targets to mitigate asthma exacerbations linked to viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and children with a history of respiratory viral infections, particularly those born prematurely or diagnosed with chronic lung diseases.
Not a fit: Patients who do not have a history of respiratory viral infections or those without allergic asthma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of asthma development and improve management of allergic responses in children.
How similar studies have performed: Previous research has shown promising results in understanding the immune response to viral infections and its link to asthma, indicating that this approach has potential for significant findings.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KEEGAN, ACHSAH D. — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: KEEGAN, ACHSAH D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: chronic lung disease in infants, chronic lung disease in neonatal infants, chronic lung disease in neonates, chronic lung disease in newborns, chronic lung disease in prematurity