How certain immune cells contribute to airway allergies
Official title: Neuronally-driven accumulation of glycolytic MafB+MHCIIhi IMs drive airway allergy
Funded at Johns Hopkins University · NIH-11094074 · Data updated 2026-11-12
This study is looking at a special type of immune cell that might play a big role in causing allergies in the airways, especially when triggered by things like dust mites, to help find new ways to understand and treat allergies better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 21, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $619,322 |
| NIH project number | 5R01AI170709-03 |
| Project ID | NIH-11094074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from allergic airway diseases, particularly those with a history of reactions to common allergens.
✕Less likely to help
Patients without allergic conditions or those who do not respond to common allergens may not benefit from this research.
What this research studies
This research investigates the role of a specific type of immune cell, known as MafB+MHCIIhi interstitial macrophages, in driving allergic responses in the airways. By examining how these cells interact with nerve signals during allergic reactions, the study aims to uncover new mechanisms behind airway inflammation caused by allergens like house dust mites. The researchers will use advanced techniques to target these immune cells and assess their contributions to the development of allergic diseases. This could lead to a better understanding of how allergies develop and potentially new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that more effectively manage or prevent allergic airway diseases.
How similar studies have gone: While the role of dendritic cells in allergies is well-established, the specific focus on MafB+MHCIIhi interstitial macrophages represents a novel approach that has not been extensively tested in prior research.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Lajoie, Stephane — Johns Hopkins University
- Study coordinator: Lajoie, Stephane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.