How certain immune cells affect brain inflammation in HIV patients
Clonal hematopoiesis in monocytes contributes to HIV-associated neuroinflammation
This study is looking at how certain immune cells called monocytes affect brain inflammation in people with HIV, especially how they might contribute to brain health issues, and it’s designed for those who are receiving treatment for HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11103216 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune cells, known as monocytes, in causing inflammation in the brain of individuals living with HIV. It focuses on how these cells cross the blood-brain barrier and contribute to neurological damage and cognitive decline. By examining the characteristics of these monocytes in patients receiving antiretroviral therapy, the study aims to understand their behavior and potential impact on brain health. The research employs various models to explore how these immune cells interact with the central nervous system and the factors that influence their activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are receiving antiretroviral therapy and experiencing neurological symptoms.
Not a fit: Patients who are not infected with HIV or those who are not undergoing antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in HIV-infected individuals.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in neuroinflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Maggirwar, Sanjay B. — George Washington University
- Study coordinator: Maggirwar, Sanjay B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.