How certain gut bacteria affect complications after blood cell transplants
Official title: Mucus-degrading intestinal bacteria and toxicities of hematopoietic cell transplantation
Funded at Beckman Research Institute/city of Hope · NIH-10935661 · Data updated 2026-11-12
This study is looking at how certain bacteria in the gut can affect the health of patients who have had a stem cell transplant, especially in relation to complications like graft-versus-host disease and fever, to see if antibiotics can help improve their recovery.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 21, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,594,544 |
| NIH project number | 1P01HL170046-01A1 |
| Project ID | NIH-10935661 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing allogeneic hematopoietic cell transplantation for hematological conditions.
✕Less likely to help
Patients who are not undergoing hematopoietic cell transplantation or those with non-hematological conditions may not benefit from this research.
What this research studies
This research investigates the role of mucus-degrading bacteria in the gut and their impact on complications following hematopoietic cell transplantation (HCT). It focuses on how these bacteria, particularly Akkermansia and Bacteroides, interact with the gut environment and contribute to conditions like graft-versus-host disease (GVHD) and neutropenic fever. By studying these interactions, the research aims to understand how antibiotic treatments can influence these bacteria and the overall health of patients undergoing HCT. The approach includes analyzing gut microbiota and its effects on patient outcomes through a series of integrated projects.
Why it matters
Potential benefit: If successful, this research could lead to improved management of complications in patients undergoing hematopoietic cell transplantation.
How similar studies have gone: Previous research has shown that gut microbiota can significantly influence patient outcomes in transplant settings, suggesting that this approach has potential for success.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Jenq, Robert — Beckman Research Institute/city of Hope
- Study coordinator: Jenq, Robert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.