How certain genetic changes affect B cell activation in lupus
Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE
This study is looking at how certain genetic changes might affect the immune system in people with lupus, especially how these changes influence B cells and their role in producing antibodies, and we're inviting lupus patients to share their genetic samples to help us learn more.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11006345 on NIH RePORTER |
What this research studies
This research investigates the role of specific genetic mutations in the NADPH oxidase complex that may contribute to the development of systemic lupus erythematosus (SLE). By examining how these mutations affect B cell activation and function, the study aims to uncover mechanisms that lead to autoimmune responses. The approach involves analyzing the impact of reduced NOX2 activity on B cells, particularly focusing on their ability to produce autoantibodies and initiate immune tolerance breaks. Patients with SLE may provide genetic samples to help understand these processes better.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with systemic lupus erythematosus, particularly those with known genetic variants in the NADPH oxidase complex.
Not a fit: Patients without systemic lupus erythematosus or those not carrying relevant genetic variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of lupus and potentially identify targets for more effective treatments.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors contributing to autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Jackson, Shaun William — Seattle Children's Hospital
- Study coordinator: Jackson, Shaun William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.