How certain enzymes affect fat and amino acid signaling in humans
Official title: CYP4F Enzymes Regulate N-Acyl Amino Acid Signaling in Humans
Funded at Beth Israel Deaconess Medical Center · NIH-11047994 · Data updated 2026-11-12
This study is looking at how certain enzymes in your body affect fat-related molecules that help control energy and sugar levels, which could help us understand the risk of obesity and type 2 diabetes, so we can find better ways to prevent and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $762,469 |
| NIH project number | 1R01DK137983-01A1 |
| Project ID | NIH-11047994 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for obesity or type 2 diabetes, particularly those with metabolic syndrome.
✕Less likely to help
Patients who are not at risk for obesity or type 2 diabetes may not benefit from this research.
What this research studies
This research investigates the role of specific enzymes, known as CYP4F enzymes, in regulating lipid signaling molecules called N-acyl amino acids, which are linked to energy balance and glucose metabolism. By analyzing data from a large cohort, the study aims to understand how these molecules can influence the risk of developing obesity and type 2 diabetes. The researchers will use advanced techniques like mass spectrometry and genome-wide association studies to explore the genetic factors that affect these signaling pathways in humans. This could lead to new insights into metabolic diseases and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating obesity and type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding lipid signaling and its implications for metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Benson, Mark Daniel — Beth Israel Deaconess Medical Center
- Study coordinator: Benson, Mark Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.