How certain enzymes affect fat and amino acid signaling in humans
CYP4F Enzymes Regulate N-Acyl Amino Acid Signaling in Humans
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11047994
This study is looking at how certain enzymes in your body affect fat-related molecules that help control energy and sugar levels, which could help us understand the risk of obesity and type 2 diabetes, so we can find better ways to prevent and treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11047994 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific enzymes, known as CYP4F enzymes, in regulating lipid signaling molecules called N-acyl amino acids, which are linked to energy balance and glucose metabolism. By analyzing data from a large cohort, the study aims to understand how these molecules can influence the risk of developing obesity and type 2 diabetes. The researchers will use advanced techniques like mass spectrometry and genome-wide association studies to explore the genetic factors that affect these signaling pathways in humans. This could lead to new insights into metabolic diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for obesity or type 2 diabetes, particularly those with metabolic syndrome.
Not a fit: Patients who are not at risk for obesity or type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating obesity and type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding lipid signaling and its implications for metabolic diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BENSON, MARK DANIEL — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: BENSON, MARK DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus