How certain elements help control gene expression in fruit flies
Regulation of long distance enhancer-promoter interactions by promoter-proximal elements
This study looks at how certain parts of the fruit fly's DNA work together to control how genes are turned on and off, helping us learn more about how these processes are important for growth and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10868564 on NIH RePORTER |
What this research studies
This research investigates how specific elements in the genome, known as promoter-proximal elements, interact with distant regulatory regions to control gene expression in fruit flies. By studying the fruit fly Drosophila melanogaster, the researchers aim to understand the mechanisms that coordinate these interactions and their importance for proper development and maintenance of biological functions. The study employs advanced techniques such as CRISPR and chromatin assays to explore these complex genetic interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions that may be linked to gene regulation issues.
Not a fit: Patients with conditions unrelated to genetic regulation or those not affected by developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gene regulation, which may inform treatments for genetic disorders and developmental diseases.
How similar studies have performed: Previous research has shown success in understanding gene regulation mechanisms, making this approach promising but still exploring novel aspects.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Stathopoulos, Angelike — California Institute of Technology
- Study coordinator: Stathopoulos, Angelike
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.