How certain chemicals affect bone health
Official title: Investigating the Perturbation of Bone Health by Per/Polyfluoroalkyl Substances
Funded at Boston University Medical Campus · NIH-10746129 · Data updated 2026-11-12
This study is looking at how certain chemicals found in everyday products might affect bone health in both kids and adults, helping us understand if they can weaken bones.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $82,500 |
| NIH project number | 5R03ES034093-02 |
| Project ID | NIH-10746129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals exposed to PFAS through contaminated water or food, particularly those with concerns about their bone health.
✕Less likely to help
Patients who have no history of PFAS exposure or existing bone health issues may not benefit from this research.
What this research studies
This research investigates the impact of per- and polyfluoroalkyl substances (PFAS), commonly found in everyday products, on bone health. It aims to understand how these chemicals may disrupt bone metabolism and reduce bone density in both children and adults. Using a novel model that mimics human biology, the study will explore the mechanisms by which PFAS interact with bone cells and nuclear receptors. The findings could provide insights into the potential risks associated with PFAS exposure and bone health.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of bone health issues related to PFAS exposure.
How similar studies have gone: While there has been significant research on PFAS effects on other health aspects, this specific focus on bone health is relatively novel and underexplored.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Schlezinger, Jennifer J — Boston University Medical Campus
- Study coordinator: Schlezinger, Jennifer J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.