How certain chemicals affect bone health
Investigating the Perturbation of Bone Health by Per/Polyfluoroalkyl Substances
This study is looking at how certain chemicals found in everyday products might affect bone health in both kids and adults, helping us understand if they can weaken bones.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10746129 on NIH RePORTER |
What this research studies
This research investigates the impact of per- and polyfluoroalkyl substances (PFAS), commonly found in everyday products, on bone health. It aims to understand how these chemicals may disrupt bone metabolism and reduce bone density in both children and adults. Using a novel model that mimics human biology, the study will explore the mechanisms by which PFAS interact with bone cells and nuclear receptors. The findings could provide insights into the potential risks associated with PFAS exposure and bone health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals exposed to PFAS through contaminated water or food, particularly those with concerns about their bone health.
Not a fit: Patients who have no history of PFAS exposure or existing bone health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of bone health issues related to PFAS exposure.
How similar studies have performed: While there has been significant research on PFAS effects on other health aspects, this specific focus on bone health is relatively novel and underexplored.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Schlezinger, Jennifer J — Boston University Medical Campus
- Study coordinator: Schlezinger, Jennifer J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.