How certain cells in the airway help control inflammation and healing
Solitary Chemosensory Cell Regulation of Airway Inflammation and Repair
This study is looking at special cells in your airways that help manage inflammation and healing, especially if you have chronic rhinosinusitis, to find out how they work and how we might use that knowledge to improve breathing health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10992124 on NIH RePORTER |
What this research studies
This research investigates the role of solitary chemosensory cells (SCCs) in regulating inflammation and repair in the airway, particularly in conditions like chronic rhinosinusitis. The study aims to understand how these rare cells, which express taste receptors, contribute to airway health and respond to inflammatory signals. By combining clinical practice with advanced training in immunology and bioinformatics, the research will explore the mechanisms behind airway inflammation and potential therapeutic targets for improving respiratory health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic rhinosinusitis or other airway inflammatory diseases.
Not a fit: Patients with non-inflammatory airway conditions or those not experiencing airway-related symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for airway diseases, improving the quality of life for patients with chronic respiratory conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of chemosensory cells in other tissues, suggesting potential for success in this novel area of airway health.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kohanski, Michael Aaron — University of Pennsylvania
- Study coordinator: Kohanski, Michael Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.