How certain cell deaths affect infections from a specific bacteria
Role of non-myeloid cells' pyroptosis in melioidosis
['FUNDING_R01'] · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · NIH-11038031
This study is looking at how a special kind of cell death affects the body’s response to infections from a germ that causes melioidosis, and it aims to find ways to boost the good responses while reducing any harm, which could help improve treatments for people with this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROSALIND FRANKLIN UNIV OF MEDICINE & SCI (nih funded) |
| Locations | 1 site (NORTH CHICAGO, UNITED STATES) |
| Trial ID | NIH-11038031 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific type of cell death, called pyroptosis, in the context of infections caused by the bacterium Burkholderia pseudomallei, which leads to a disease known as melioidosis. The study focuses on how the activation of certain proteins (caspase-1 and caspase-11) in different types of cells can either protect the body from infection or cause harmful effects. By using mouse models, researchers aim to understand the balance between protective and harmful responses in the lungs and blood vessels during infection. This knowledge could help in developing new treatments that enhance protective responses while minimizing damage to the body.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals at risk for melioidosis, particularly those with compromised immune systems or underlying health conditions.
Not a fit: Patients who are not affected by bacterial infections or do not have risk factors for melioidosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for melioidosis and similar bacterial infections by harnessing the body's immune responses.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammasomes in infections, suggesting that this approach could yield valuable insights.
Where this research is happening
NORTH CHICAGO, UNITED STATES
- ROSALIND FRANKLIN UNIV OF MEDICINE & SCI — NORTH CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RE, FABIO C — ROSALIND FRANKLIN UNIV OF MEDICINE & SCI
- Study coordinator: RE, FABIO C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease